Successful treatment of acquired hypoprothrombinemia without associated lupus anticoagulant using intravenous immunoglobulin.
نویسندگان
چکیده
منابع مشابه
A mechanism for the hypoprothrombinemia of the acquired hypoprothrombinemia-lupus anticoagulant syndrome.
Antibodies that bind prothrombin without neutralizing its coagulant activity were demonstrated in the plasma of two patients with the acquired hypoprothrombinemia-lupus anticoagulant syndrome. The first patient's plasma contained less than 1% prothrombin activity and no detectable prothrombin antigen. The second patient's plasma contained about 6% of both prothrombin activity and antigen. Neith...
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Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS), a very rare disease that is caused by the presence of antifactor II antibodies, is usually counterbalanced by the prothrombotic effect of lupus anticoagulant (LAC). Patients with LAHPS are treated using fresh frozen plasma, steroids, immunosuppressive agents, and immunoglobulins for managing the disease and controlling hemorrhages. Notab...
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By SAMUEL I. RAPAPORT, S r A BETH AMES AND BARBARA J. DUVALL C ONLEY AND HARTMANN’ first called attention to a plasma coagulation disturbance peculiar to patients with systemic lupus erythematosus or closely related dysproteinemias. Its characteristics are a long whole blood and/or recalcified plasma clotting time, a long Quick “prothrombin” time, and the presence of a circulating anticoagulant...
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The presence of lupus anticoagulant is associated with an elevated risk of venous and arterial thrombosis, and recurrent miscarriages as well. For some cases, this disease can present with bleeding as a consequence of lupus anticoagulant hypoprothrombinemia (LAHPS). LAHPS is a rare disease and it is reported to be most frequent in young females with/without systemic lupus erythematosus or in he...
متن کاملAnti-prothrombin antibodies and the lupus anticoagulant.
The investigators have evaluated the frequency and manifestations of anti-prothrombin antibodies in patients with the lupus anticoagulant. Thirty-one of 42 patients with lupus anticoagulants associated with a variety of underlying conditions (74%) had evidence on crossed immunoelectrophoresis of anti-prothrombin antibodies. Twenty-four of 25 patients with an activated partial thromboplastin tim...
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ورودعنوان ژورنال:
- Haematologica
دوره 86 5 شماره
صفحات -
تاریخ انتشار 2001